Minimally Invasive Autopsy Improves Postmortem Diagnoses

Permanent record of the entire body can be revisited and reanalyzed for future research.


Minimally invasive autopsy with CT and MRI performs as well as conventional autopsy in detecting cause of death and has the advantage of yielding more diagnoses, according to a study in Radiology.

Conventional autopsies yield a wealth of information, including insights into new diseases and the side effects of drugs while providing data for health statistics and epidemiologic studies and tissue for molecular studies. They are important for teaching pathology in medical school and training medical specialists. Perhaps most importantly, autopsies can answer central questions surrounding the cause of death, said the study’s senior author, J. Wolter Oosterhuis, MD, PhD, from the Department of Pathology at Erasmus University Medical Center in Rotterdam, the Netherlands.

“Since in about 15 percent of cases autopsy reveals an unexpected cause of death, it provides important feedback to clinicians, to the benefit of future patients,” Dr. Oosterhuis said. 

Despite the importance of conventional autopsies, rates have been rapidly declining, the study authors said, for a variety of reasons, including reluctance of next-of-kin due to the invasiveness of the procedure. In the face of this trend, non-invasive or minimally invasive alternative autopsy methods have emerged as potentially valuable options. Postmortem CT and MRI enable visualization of the entire body, and image-guided tissue biopsies can be obtained for further examination.

Dr. Oosterhuis and colleagues recently compared the performance of minimally invasive autopsy to that of conventional autopsy in 99 deceased humans. The minimally invasive autopsy procedure combined post-mortem MRI, CT and CT-guided biopsies of the main organs and pathological lesions. 
minimally invasive autopsy improves postmortem diagnoses
Images in 60-year old man who underwent bilateral lung transplant 2 months before death. Images show aorta (∗ in A and B), carotid arteries (arrows in B), visceral blood vessels (cerebral blood vessels: arrows in A, C, D; liver blood vessel: arrow in F), and right ventricle (oval in E). G, Photomicrograph of luminal side of trachea shows disappearance of mucosa and submucosa; tracheal cartilage is necrotic with empty lacunae, nuclear debris (arrows), and clefts (∗). H, I, Photomicrographs of myocardium show blood vessels inflated by air that pushes erythrocytes to the walls and causes rupture of vessels (arrows), allowing air (∗) and erythrocytes (oval in I) to escape into interstitial space, thereby tearing the tissue.
Image-Guided Autopsies Showed Similar Performance as Conventional Autopsy

The researchers found agreement between minimally invasive autopsy and conventional autopsy for cause of death in 92 percent of the cases. There was agreement with the consensus cause of death in 96 of 99 of the cases of minimally invasive autopsy, compared with 94 of 99 for conventional autopsy. 

The total number of diagnoses established by minimally invasive autopsy was higher than that of regular autopsy. The deceased patients had a total of 288 major diagnoses related to the consensus cause of death and minimally invasive autopsy diagnosed 259 of those, or 90 percent, compared with 78 percent for conventional autopsy.

“With minimally invasive autopsy, the body is investigated from top to toe, and with regular autopsy usually only the torso and, if consented by next-of-kin, the brain,” Dr. Oosterhuis said. “Moreover, postmortem CT and MRI demonstrate pathology, in particular of the skeleton and soft tissues, which is easily missed by the regular autopsy.”

According to Dr. Oosterhuis, minimally invasive autopsy presents a potentially more desirable option for next-of-kin who may be reluctant to approve the conventional procedure on religious grounds. 

Minimally invasive autopsy has the additional benefit of providing information that can be stored for long-term use. 

“It’s very important to note that conventional autopsy cannot be redone, and items that were overlooked or misinterpreted cannot be corrected,” Dr. Oosterhuis said. “Minimally invasive autopsy, on the other hand, provides a permanent record of the entire body that can be revisited, and reanalyzed by pathologists, radiologists, clinicians and next-of-kin. For scientists, this dependable database has great potential for future research.”