Measurement of thalamic atrophy and increase in ventricular size in clinically isolated syndrome (CIS) is associated with clinically definite multiple sclerosis (CDMS) development and should be used in addition to the assessment of new T2 and contrast agent-enhanced lesions, according to new research.
Robert Zivadinov, M.D., Ph.D., of the Buffalo Neuroimaging Analysis Center, University at Buffalo, N.Y., and colleagues used contrast-enhanced MR imaging for initial assessment of 216 CIS patients. Follow-up scans were performed at six months, one year and two years. Over two years, 92 of 216 patients, or 42.6 percent, converted to clinically definite MS. Decreases in thalamic volume and increase in lateral ventricle volumes were the only MR imaging measures independently associated with the development of clinically definite MS.
Development of thalamic and central atrophy is associated with conversion to clinically definite multiple sclerosis (CDMS) over two years, and measurement should be used in addition to the assessment of new CE lesions and T2 lesions, according to the authors. “Use of these MR imaging biomarkers may be relevant for identifying patients who are at high risk for conversion to CDMS in future clinical trials involving CIS patients,” the authors write.
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