There is no significant relationship between multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI) with regard to cerebral hemodynamic parameters, according to new research.
In the study, http://radiology.rsna.org/content/early/2012/08/03/radiol.12112245.full?sid=05bffeac-8863-4c1c-acf4-a175a07429b9 Francesco G. Garaci, M.D., of the University of Rome Tor Vergata, Italy, and colleagues assessed cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time with dynamic susceptibility contrast material–enhanced MR imaging in normal-appearing white matter (NAWM) in 39 patients with MS. Of those, 25 had CCSVI and 14 did not. Of the 26 healthy control subjects also evaluated, 14 had CCSVI and 12 did not.
Patients with CCSVI showed cerebral hemodynamic anomalies such as decreased CBF and CBV compared with individuals without CCSVI, without any delay in mean transit time. No significant interac tion between MS and CCSVI was found for any hemodynamic parameters and no correlations were found between CBV and CBF values in NAWM or for severity of disability in patients with MS, according to results.
"Our results show that CCSVI has no effect on neurologic function and disability progression in MS, since no correlations were found between the hemodynamic abnormalities related to CCSVI and two direct measures of disability (Expanded Disability Status Scale and MS Severity Score)," the authors write. "Therefore, these results favor the hypothesis that CCSVI has no role in MS pathogenesis."
Moderate leukoaraiosis is associated with atypical functional activation during semantic decision tasks in the elderly, according to new research. Consequently, leukoaraiosis is an important confounding variable in functional MR imaging studies of the elderly.
In the study, http://radiology.rsna.org/content/early/2012/08/03/radiol.12112052.full?sid=7e731ce6-1a0f-4029-b55a-2333b2565d1c
Kirk M. Welker, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues performed functional MR imaging on 18 right-handed, cognitively healthy elderly participants with an aggregate leukoaraiosis lesion volume of more than 25 cm3 and 18 age-matched control participants with less than 5 cm3 of leukoaraiosis.
Researchers compared activation in patients performing semantic decisions with those making visual perceptual decisions. Results showed that elderly patients with moderate leukoaraiosis exhibit atypical activation patterns during a functional MR imaging semantic decision task in comparison with age-matched healthy control participants.
"Participants with leukoaraiosis experience less language, primary visual, and basal ganglia activation during semantic decisions and increased visual-spatial activation during visual perceptual decisions," according to researchers. "On the basis of these results, we believe that researchers performing functional MR imaging language studies in elderly patients should address participants’ leukoaraiosis levels in their experimental procedure."
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To highlight National Breast Cancer Awareness Month in October and National Lung Cancer Awareness Month in November, RSNA is distributing public service announcements (PSAs) focusing on the importance of regular screening mammograms and the symptoms, risk factors and possible treatment options related to lung cancer.
In addition to the PSAs, RSNA is distributing the “60-Second Checkup” audio program focusing on better prognoses for women ages 40 to 49 who have breast cancer detected through mammography and treatment options for small cell versus non-small cell lung cancer patients.
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