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  • Radiology in Public Focus

    March 01, 2014

    Press releases were sent to the medical news media for the following articles appearing in recent issues of Radiology.

    Mapping the Effect of the Apolipoprotein EGenotype on 4-Year Atrophy Rates in an Alzheimer Disease-related Brain Network

    The apolipoprotein E (APOE) genotype (ɛ4) allele is associated with accelerated rates of atrophy in a specific gray matter network of vulnerable brain regions among subjects at risk for Alzheimer disease (AD), new research shows.

    Christopher A. Hostage, M.D., of the Duke University School of Medicine and the Alzheimer’s Disease Neuroimaging Initiative (ADNI), and colleagues analyzed data from 237 subjects (mean age, 79.9 years; 40 percent female) with mild cognitive impairment (MCI) in the ADNI database and assessed the effect of the APOE genotypes ɛ4 and ɛ2 alleles on regional brain atrophy rates over a 12-48-month period. Regional atrophy rates were derived by using a fully automated algorithm applied to T1-weighted MR imaging data.

    According to results, 13 of 15 experimental regions showed a significant effect of ɛ4 or higher atrophy rates (P < .001 for all). Cohen d values ranged from 0.26 to 0.42, with the largest effects seen in the amygdalae and hippocampi. The transverse temporal cortex showed a trend (P = .02, but did not survive Bonferroni correction) for a protective effect (Cohen d value = 0.15) of ɛ2. No control region showed an APOE effect.

    “The additional rate of atrophy in vulnerable brain regions—regions that typically display marked degeneration in AD—that is directly attributable to APOE ɛ4 is comparable in magnitude to the underlying age-related, baseline rate of atrophy observed for these areas in ɛ4 noncarriers,” the authors write.

    Media Coverage of RSNA

    Radiology, March 2014In December, media outlets carried 5,914 RSNA-related news stories. These stories reached an estimated 2.6 billion people.

    Print and online coverage included The Huffington Post, U.S News & World Report, The Wall Street Journal, Yahoo! News, Los Angeles Times, BBC News, The Atlanta Journal-Constitution, Examiner.com, WebMD, FOXNews.com, Toronto Telegraph, Newsday, New York Post, Glamour, Self, Prevention and Shape.

    Broadcast coverage included Doctor Radio, Fox News Channel, Al Jazeera America, WGN America, WABC-TV (New York), WNBC-TV (New York), KABC-TV (Los Angeles), WMAQ-TV (Chicago), WLS-TV (Chicago) and WBBM-TV (Chicago).

    Media coverage of RSNA 2013 will be highlighted in a future issue of RSNA News.

    Read coverage of RSNA in these media:

    New on RadiologyInfo.org

    RadiologyInfo.orgVisit RadiologyInfo.org, the RSNA and ACR’s jointly-sponsored public information website, to read the latest disease/condition topics, including:

    March Public Information Outreach Activities Focus on Colorectal Cancer

    To highlight National Colorectal Cancer Awareness Month in March, RSNA is distributing radio public service announcements (PSAs) encouraging listeners to be screened for colorectal cancer.

    In addition, RSNA is distributing the “60-Second Checkup” audio program to nearly 100 radio stations across the U.S. The segments focus on colorectal cancer screening and the types of exams available.

    Medial, inferior, superior and lateral images of a 3D FreeSurfer reference brain model
    Medial, inferior, superior and lateral images of a 3D FreeSurfer reference brain model show regions of accelerated atrophy in the presence of APOE ɛ4 in subjects with mild cognitive impairment. Effect size of the APOE ɛ4 acceleration of cortical atrophy is depicted by color: Blue signifies a magnitude of Cohen d value of less than 0.25; yellow, 0.25–0.35; and red, more than 0.35. Gray areas were not examined. (Radiology 2014;270;2:InPress) ©RSNA, 2014. All rights reserved. Printed with permission.
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