• News App
  • To:
  • Journal Highlights

    October 01, 2013

    The following are highlights from the current issues of RSNA’s two peer-reviewed journals.

    Longitudinal in vitro evaluations of FITC-ferumoxytol–labeled MSCs
    (Click to enlarge) Longitudinal in vitro evaluations of FITC-ferumoxytol–labeled MSCs.  Fluorescence microscopy demonstrates green fluorescence signal of in vivo FITC-ferumoxytol–labeled cells. The fluorescence signal slowly declines over time. Corresponding T2 relaxation time maps of cell pellets in test tubes show shortening of T2 relaxation times of in vivo–labeled cell pellets compared with unlabeled control pellets, which also decreases slowly over time. Color spectrum = color scale for T2 time (milliseconds) that signifies MR signal intensity of the pellet; the more iron (ferumoxytol) the cells contain, the lower the T2 value. LIV = labeled in vivo, C = control cells.

    (Radiology 2013;269;1:186–197) ©RSNA, 2013. All rights reserved. Printed with permission. 

    Iron Administration Before Stem Cell Harvest Enables MR Imaging Tracking after Transplantation

    To monitor successful engraftment and recognize complications such as graft failure or tumor formation, marrow–derived mesenchymal stem cell (MSC) therapies require in vivo tracking of the transplanted stem cells with noninvasive imaging technologies.

    In a study published in the October issue of Radiology (RSNA.org/Radiology), to determine whether intravenous ferumoxytol can be used to effectively label MSCs in vivo and for tracking of stem cell transplants, Aman Khurana, M.D., of Stanford University School of Medicine, and colleagues injected Sprague-Dawley rats with ferumoxytol 48 hours prior to extraction of MSCs from bone marrow.

    Ferumoxytol uptake by these MSCs was evaluated with fluorescence, confocal and electron microscopy and compared with results from traditional ex vivo-labeling procedures. The in vivo-labeled cells were subsequently transplanted in osteochondral defects of 14 knees of seven athymic rats and evaluated with MR imaging up to four weeks after transplantation.

    In vivo ferumoxytol-labeled MSCs, harvested from bone marrow and transplanted into osteochondral knee defects, showed significantly shortened T2 relaxation times compared with unlabeled control cells (15.459 vs. 24.423 msec, P =.0002). Histologic examination confirmed the presence of iron in labeled transplants and defect remodeling.

    “We developed an immediately available, potentially clinically applicable approach for in vivo stem cell labeling with an FDA-approved iron supplement,” the authors write.

    Dysplastic nodule in segment V of the liver
    (Click to enlarge) Dysplastic nodule in segment V of the liver in a 61-year-old man with cirrhosis. Axial image from MR elastography demonstrates that the dysplastic nodule has lower stiffness (green), compared with the adjacent cirrhotic liver parenchyma (red).

    (RadioGraphics 2013;33;:1781-1800) ©RSNA, 2013. All rights reserved. Printed with permission. 

    Assessment of Liver Tumor Response to Therapy: Role of Quantitative Imaging

    The substantial recent progress in nonsurgical therapeutic options for malignant primary and metastatic liver tumors has created a new challenge for radiologists who must assess the response of liver tumors to therapy.

    During the costly and time-consuming steps of clinical trials to obtain regulatory approval of drugs and for the efficacy evaluation of locoregional therapies for hepatic malignancies, imaging biomarkers can provide reliable quantitative assessment of tumor treatment response by acting as surrogate endpoints to the traditional survival-based endpoints. Accurate evaluation of the efficacy of new therapies at earlier stages is crucial to avoid potential toxic reactions, unnecessary interventions and costly failure.

    In an article in the October Special Issue of RadioGraphics (RSNA.org/RadioGraphics), Fernanda D. Gonzalez-Guindalini, M.D., of Northwestern Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, and colleagues review the current quantification criteria used in the evaluation of treatment response in liver tumors, summarizing their indications advantages and disadvantages, and discuss future directions with newer methods that have the potential for assessment of treatment response.

    “Quantitative imaging allows robust evaluation of hepatic tumor response. In addition to size changes, various biologic and functional parameters can be quantified by using new imaging technologies,” the authors write. “Measurement of these parameters is especially important for the evaluation of tumor response to novel targeted therapies, in which change in functional status sometimes precedes anatomic modification.”

    This article meets the criteria for AMA PRA Category 1 Credit™. SA-CME is available online. 
  • comments powered by Disqus

We appreciate your comments and suggestions in our effort to improve your RSNA web experience.

Name (required)


Email Address (required)


Comments (required)





Discounted Dues: Eligible North American Countries 
Costa Rica
Dominican Republic
El Salvador
Netherlands Antilles
St. Vincent & Grenadines
Country    Country    Country 
Afghanistan   Grenada   Pakistan
Albania   Guatemala   Papua New Guinea
Algeria   Guinea   Paraguay
Angola   Guinea-Bissau   Peru
Armenia   Guyana   Phillippines
Azerbaijan   Haiti   Rwanda
Bangladesh   Honduras   Samoa
Belarus   India   Sao Tome & Principe
Belize   Indonesia   Senegal
Benin   Iran   Serbia
Bhutan   Iraq   Sierra Leone
Bolivia   Jordan   Solomon Islands
Bosnia & Herzegovina   Jamaica   Somalia
Botswana   Kenya   South Africa
Bulgaria   Kiribati   South Sudan
Burkina Faso   Korea, Dem Rep (North)   Sri Lanka
Burundi   Kosovo   St Lucia
Cambodia   Kyrgyzstan   St Vincent & Grenadines
Cameroon   Laos\Lao PDR   Sudan
Cape Verde   Lesotho   Swaziland
Central African Republic   Liberia   Syria
Chad   Macedonia   Tajikistan
China   Madagascar   Tanzania
Colombia   Malawi   Thailand
Comoros   Maldives   Timor-Leste
Congo, Dem. Rep.   Mali   Togo
Congo, Republic of   Marshall Islands   Tonga
Cote d'Ivoire   Mauritania   Tunisia
Djibouti   Micronesia, Fed. Sts.   Turkmenistan
Dominica   Moldova   Tuvalu
Domicican Republic   Mongolia   Uganda
Ecuador   Montenegro   Ukraine
Egypt   Morocco   Uzbekistan
El Salvador   Mozambique   Vanuatu
Eritrea   Myanmar   Vietnam
Ethiopia   Namibia   West Bank & Gaza
Fiji   Nepal   Yemen
Gambia, The   Nicaragua   Zambia
Georgia   Niger   Zimbabwe
Ghana   Nigeria    

Legacy Collection 2
Radiology Logo
RadioGraphics Logo 
Tier 1

  • Bed count: 1-400
  • Associate College: Community, Technical, Further Education (UK), Tribal College
  • Community Public Library (small scale): general reference public library, museum, non-profit administration office

Tier 2

  • Bed count: 401-750
  • Baccalaureate College or University: Bachelor's is the highest degree offered
  • Master's College or University: Master's is the highest degree offered
  • Special Focus Institution: theological seminaries, Bible colleges, engineering, technological, business, management, art, music, design, law

Tier 3

  • Bedcount: 751-1,000
  • Research University: high or very high research activity without affiliated medical school
  • Health Profession School: non-medical, but health focused

Tier 4

  • Bed count: 1,001 +
  • Medical School: research universities with medical school, including medical centers

Tier 5

  • Consortia: academic, medical libraries, affiliated hospitals, regional libraries and other networks
  • Corporate
  • Government Agency and Ministry
  • Hospital System
  • Private Practice
  • Research Institute: government and non-government health research
  • State or National Public Library
  • Professional Society: trade unions, industry trade association, lobbying organization