High-signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted images may be a consequence of the number of previous gadolinium-based contrast material administrations, according to new research.
In the study, Tomonori Kanda, M.D., Ph.D., of the Hyogo Cancer Center, Akashi, Japan, and colleagues compared unenhanced T1-weighted MR images (T1WI) of 19 patients who had undergone six or more contrast-enhanced brain scans with 16 patients who had received six or fewer unenhanced scans. The hyperintensity of both the DN and the GP correlated with the number of gadolinium-based contrast material administrations.
Results showed high-signal intensity of both the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images correlates with the number of previous gadolinium-based contrast medium administrations (dentate nucleus: P < .001, regression coefficient = 0.010, 95 percent confidence interval [CI]: 0.009, 0.011; globus pallidus: P < .001, regression coefficient = 0.004, 95 percent CI: 0.002, 0.006).
“Gadolinium deposition, or high-signal intensity material deposition related to cumulative gadolinium load, occurs in the human brain independent of renal function,” the authors write.
The combination of choline/creatine (Cho/Cr) and N-acetylaspartate (NAA) ratios measured in the posterior periventricular white matter at term-equivalent age is predictive of motor outcome at 1 year in infants born at less than 32 weeks gestation, new research shows.
Giles S. Kendall, M.R.C.P.H., Ph.D., of the University College London, and colleagues examined 43 infants (24 boys) born at less than 32 weeks gestation and admitted for neonatal intensive care. Researchers performed single-voxel point-resolved proton (hydrogen 1) MR spectroscopy from a 2-cm3 voxel centered in the posterior periventricular white matter.
Abnormal motor outcome at 1 year can be predicted with a cerebral white matter N-acetylaspartate (NAA)–to-choline (Cho) ratio of less than 0.725 and a Cho-to-creatine (Cr) ratio of more than 2.425 at proton MR spectroscopy performed at term-corrected age, results showed. An increased Cho/Cr ratio and a decreased NAA/Cho ratio can predict impaired motor outcome at a corrected age of 1 year, with a sensitivity of 0.80 (95 percent confidence interval [CI]: 0.57, 0.94) and specificity of 0.80 (95 percent CI: 0.66, 0.88).
“Cho/Cr and NAA/Cho ratios have the potential to be used as surrogate endpoints in neuroprotection trials in preterm babies; in addition, they may indicate at an early stage those babies who may benefit from ongoing intervention in infancy,” the authors concluded.
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