RE Foundation

Researcher Investigates the Feasibility of Abbreviated Breast MRI

Heacock
Heacock

Abbreviated breast MRI (AB-MRI) is a short set of breast imaging sequences which demonstrate promise in diagnosing breast cancer with decreased imaging time compared to conventional breast MRI.

In her study, “Abbreviated Breast MRI (AB-MRI) with Golden-angle Radial Compressed-sensing and Parallel Imaging (GRASP): A Short, Comprehensive Breast MRI Exam Ready for Clinical Prime Time,” Laura Heacock, MD, MS, New York University, is using her 2018 Fujifilm Medical Systems/RSNA Research Seed Grant to investigate the use of a fast temporal resolution compressed sensing MRI sequence in an AB-MRI screening protocol.

Incorporating fast temporal resolution imaging may improve the specificity of AB-MRI by providing quantitative information on the wash-in of gadolinium. Use of this imaging technique in AB-MRI could therefore increase breast MRI screening accessibility, particularly for women with intermediate and high lifetime risk of breast cancer.

“Our novel multicoil compressed sensing sequence, Golden-angle Radial Sparse Parallel imaging (GRASP), offers both high spatial and temporal resolution in the same acquisition with flexible temporal reconstruction,” Dr. Heacock said. “Use of GRASP in AB-MRI can offer both high sensitivity and specificity for breast cancer detection, with reconstructed images providing temporal kinetic data incorporated into the clinical work-flow and available for real-time interpretation by breast imagers.”

In this study, Dr. Heacock and her team will evaluate the diagnostic accuracy of GRASP wash-in temporal kinetics in the diagnosis of breast malignancies and test the results in a validation cohort.

“Our central hypothesis is that the combination of spatial morphology and temporal kinetics in GRASP AB-MRI can decrease the number of lesions recommended for short-term follow-up and reduce the rate of unnecessary biopsies compared to conventional DCE-MRI,” Dr. Heacock said. “The results of this study will serve as preliminary analysis for future use of GRASP AB-MRI in intermediate and high-risk screening populations.”