Biomarkers and neuroimaging have great potential to increase the power of clinical trials for Alzheimer disease (AD) through greater effect by matching imaging methodology with therapeutic mechanism.
Radiologists can play a role in biomarker development, treatment monitoring in clinical trials and ultimately, in development of accurate diagnostic tests for patient care, according to a study in the December issue of Radiology (RSNA.org/Radiology) led by Jeffrey Petrella, M.D., of Duke University Medical Center, Durham, N.C. Researchers describe the progress made toward developing treatments designed to significantly slow or halt the progression of AD as well as a means of early identification of patients who may be candidates for such interventions. The authors also discuss:
“In addition to a critical role in trials, structural, molecular, and functional imaging techniques can give us a window on the etiology of AD and other neurodegenerative diseases,” the authors write. “This combination of developments has potential to bring diagnostic radiology to the forefront in AD research, therapeutic trials, and patient care.”
Although CT enterography and MR enterography have become the imaging modalities of choice for inflammatory bowel disease (IBD), each has advantages and disadvantages in terms of diagnosing pediatric IBD.
In an article in the November-December issue of RadioGraphics (RSNA.org/RadioGraphics), Alexander J. Towbin, M.D., of Cincinnati Children’s Hospital Medical Center, and colleagues discuss the use of CT enterography and MR enterography in the context of pediatric IBD in terms of advantages and disadvantages, protocol and imaging findings.
Although CT enterography has many advantages over other radiologic and endoscopic modalities, its main disadvantage is its reliance on ionizing radiation. This has limited its use and has helped MR enterography become the primary method of evaluating the pediatric bowel. In addition to being radiation free, MR enterography can help evaluate peristalsis, has high contrast resolution and allows the use of diffusion-weighted imaging.
CT enterography and MR enterography are similar imaging tests, each capable of helping identify IBD in a sensitive and specific manner, according to the authors.
“We have been able to perform CT enterography and MR enterography reliably in children as young as 2 years of age,” the authors write. “Because the findings of pediatric IBD mirror those of adult disease in many ways, radiologists are able to interpret intestinal and extraintestinal findings in a wide range of patients.”
This study features an Invited Commentary by Jonathan R. Dillman, M.D., University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor.
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