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Leading the News
Research
Technology
Medical-Legal Issues
Clinical Practice
Industry News

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From RSNA


Featured in RadioGraphics: Best Cases from the AFIP

In a new case from the Armed Forces Institute of Pathology, learn more about the clinical imaging and pathologic evaluation of urachal carcinoma.

Ultrasound, CT and MR imaging, with their ability to display cross-sectional images, are ideally suited for demonstrating urachal anomalies. This article uses a case study of a 58-year-old male patient to detail the imaging features and pathologic evaluation of urachal carcinoma, as well as prognosis and treatment.

Read more about “Urachal Carcinoma,” by Ingrid M. Koster, M.D., and colleagues, in RadioGraphics.

Leading the News


Battle Looms Over Funding Cuts for MRIs

Healthcare overhaul legislation that the U.S. Congress is considering contains a provision to reduce Medicare payments to doctors offering magnetic resonance imaging (MRI) scans and other imaging tests in their offices, which has a coalition of physicians and medical imaging equipment manufacturers up in arms. President Obama and some Democratic lawmakers claim the cuts will help reduce overuse of such tests, while critics retort that patients' access to such scans could be significantly curtailed because the provision could force some doctors out of the testing business. Opponents say paying doctors less for performing in-office tests will make the practice unaffordable for some, and the stoppage of such testing means that doctors would send patients to hospitals that could require long waits or long trips. "There are a lot of small towns [where doctors] are doing [computerized tomography] and MRIs, and I don't think they're going to be able to stay in business," warns Breast Center of Northwest Arkansas radiologist Steven Harms. Physicians who carry out MRIs and other tests in their offices have been investigated in recent years because of financial links some have to the testing facilities, and two years ago the Centers for Medicare & Medicaid Services said that this scheme can encourage doctors to order unnecessary tests to raise profits. Access to Medical Imaging Coalition lobbyist Tim Trysla stresses that Capitol Hill and the Obama administration must study the effects of the proposed legislation further. "When someone has delayed health care, that is certainly not good," he notes.

From "Battle Looms Over Funding Cuts for MRIs"
USA Today (07/17/09) Fritze, John


Research


Coronary Artery Calcification Scans Can Raise Cancer Risks

New research indicates that repeated coronary artery calcification (CAC) scans could lead to cancer in those being diagnosed. The study found that as many as 42 out of every 100,000 patients screened every five years from ages 45 to 75 could develop radiation-induced cancer. "These radiation risk estimates can be compared with potential benefits from screening, when such estimates are available," wrote Dr. Kwang Pyo Kim, now with the Department of Nuclear Engineering at Kyung Hee University in Gyeonggi-do, South Korea, and colleagues. For the purposes of the study, radiation doses delivered to adult patients were calculated from available protocols using Monte Carlo radiation transport. Radiation risk models, derived using data from Japanese atomic bomb survivors and medically exposed cohorts, were then used to estimate the excess lifetime risk of radiation-induced cancer.

From "Coronary Artery Calcification Screening: Estimated Radiation Dose and Cancer Risk"
Archives of Internal Medicine (07/13/09) Vol. 169, No. 13, P. 1188; Kim, Kwang Pyo; Einstein, Andrew J.; de Gonzalez, Amy Berrington


Gadofosveset-Enhanced MRA of the Pedal Vasculature in Patients With Diabetes Mellitus Shown to Be Superior to DSA

The purpose of this study by researchers at Johannes Gutenberg University in Mainz, Germany, was to compare gadofosveset-enhanced magnetic resonance angiography (MRA) of the pedal vasculature with selective intraarterial digital subtraction angiography (DSA). Eighteen patients with peripheral arterial occlusive disease (PAOD) and type II diabetes were prospectively examined. MR imaging consisted of dynamic and of high-resolution steady-state imaging, and selective DSA was performed within five days and served as standard of reference. Image analysis was done by two observers. Gadofosveset-enhanced MRA of the pedal vasculature proved to be superior to DSA, offering a long imaging time window and allowing for better depiction of the pedal outflow. Steady-state imaging delineated inflammatory complications associated with the diabetic foot.

From "Gadofosveset-Enhanced MR Angiography of the Pedal Arteries in Patients With Diabetes Mellitus and Comparison With Selective Intraarterial DSA"
European Radiology (07/09/09) Röhrl, Boris; Kunz, Rainer Peter; Oberholzer, Katja


Technology


Fist-Sized Tumor Removed From Brain With Help of New 3-D Brain Mapping

A surgical team from the Brain Tumor Center at the University of Cincinnati Neuroscience Institute successfully removed a fist-sized tumor from a patient's brain using a new technology that combines four different types of images into a three-dimensional brain map. "The ability to completely map the brain and to understand—before we operate—where the tumor lies in relation to important structures is a milestone in our use of digital computer technology to heighten patient safety during complex brain tumor surgery," said Mayfield Clinic neurosurgeon John Tew, MD. The four scans were integrated and installed into a surgical guidance computer, which revealed the growth's relationship to all of the brain's functional centers, electrical pathways, and blood vessels so that the surgeons could plot out a safe route to the tumor. The fusion of three types of imaging—magnetic resonance imaging, functional magnetic resonance imaging, and diffusion tensor imaging—has been used by Brain Tumor Center specialists as a guide to stereotactic surgery since early 2007. In the latest development, specialists added the fusion of computed tomography angiography, which provides a map of blood vessels.

From "Fist-Sized Tumor From Brain With Help of New 3-D Brain Mapping"
Science Daily (07/14/09)


New Tests Help Spot Early-Stage Alzheimer's

The findings of a five-year study of the brain changes that indicate the advancement of Alzheimer's disease were presented at an Alzheimer's Association conference in Vienna, Austria, and research has found that new tests evaluating brain changes and body chemistry may show potential as diagnostic tools for detecting the early onset of Alzheimer's. "The idea is if there could be biological markers identified that tracked what was going on in the brain, this would give you a better idea of whether a drug was having a biological effect," said Neil Buckholtz of the U.S. National Institute on Aging's Alzheimer's Disease Neuroimaging Initiative (ADNI) in a telephone interview. Irish researchers discovered that magnetic resonance imaging scans measuring brain volume in the left hippocampus and a combination of memory tests accurately identified almost 95 percent of people who had progressed from mild cognitive impairment to early Alzheimer's. Meanwhile, U.S. researchers found that positron emission tomography scans that measure glucose combined with low scores on memory tests could yield a strong prediction of disease progression. Buckholtz anticipates that the ADNI study will produce many more research findings. "The idea is we are trying to define the best biomarkers or combination of biomarkers that will allow us to assess progress," he noted.

From "New Tests May Help Spot Early-Stage Alzheimer's"
Reuters (07/14/09) Steenhuysen, Julie


Fluorescent Probes Permit Monitoring of Chemotherapy Effectiveness

Real-time monitoring of chemotherapy effectiveness against tumors may be enabled by fluorescent probes that allow the apoptosis of tumor cells to be observed, and Stanford University School of Medicine researchers have worked out such a method. They established that noninvasive imaging of the degree of apoptosis occurring in living animals' tumors is possible, facilitating measurement of the efficacy of apoptosis-inducing treatments. One technique for determining whether the treatment is effective is to monitor enzymes called caspases, which trigger a chain of molecular steps that govern apoptosis when activated by biochemical cues from inside or outside the cell. The researchers attached fluorescent "tags" to small molecules designed to adhere to caspases when they are active, and the probes are stimulated by certain wavelengths of light that travel through skin without being absorbed, emitting their own light in response. A special detector is used to image this light. An early test of the probe involved the administration of an apoptosis-inducing drug called dexamethasone to mice, and fluorescence was induced in the thymus as expected. Follow-up experiments involved a new, monoclonal antibody that triggers caspases and induces apoptosis, particularly in rapidly dividing cells such as those found in tumors. Fluorescence was seen in the tumor cells undergoing apoptosis, but not in the surrounding healthy tissue. The activation of caspases is a very early apoptosis event, and its monitoring could accelerate clinicians' ability to observe the effectiveness of new anti-tumor drugs, says Stanford Cancer Center professor Matthew Bogyo, PhD.

From "Noninvasive Optical Imaging of Apoptosis by Caspase-targeted Activity-based Probes"
Nature Medicine (07/09) Edgington, Laura E.; Berger, Alicia B.; Bogyo, Matthew; et al.


Medical-Legal Issues


House Bill Would Make Healthcare a Right

House Democratic leaders have tabled a plan that would for the first time designate healthcare a right and a responsibility for all Americans. Under the proposal, the federal government would be responsible for ensuring that every person has access to an affordable insurance plan, regardless of income or health. The measure calls for a 5.4 percent tax increase on individuals making more than $1 million a year, with a gradual tax beginning at $280,000 for individuals. Employers that fail to provide coverage would be hit with a penalty equivalent to 8 percent of workers' wages, with an exemption for small businesses. Individuals declining an offer of affordable coverage would pay 2.5 percent of their incomes as a penalty, up to the average cost of a health insurance plan. Though not officially released, total costs for the plan are estimated at $1.5 trillion over 10 years.

From "House Bill Would Make Healthcare a Right"
Associated Press (07/15/09) Werner, Erica


Obama Eyes the Purse Strings for Medicare

The White House is seeking to wrest control over Medicare reimbursement rates away from lawmakers, which could prove difficult given that congressional authority has proven its merit in drawing votes for lawmakers. The Obama administration has tabled two proposals aimed at achieving its goal. One would empower MedPAC to determine cuts and changes to Medicare, while the other would create a similar entity, called the Independent Medicare Advisory Council, to make Medicare recommendations to the president. Congress could vote to overturn decisions but would no longer tailor Medicare spending to address local concerns.

From "Obama Eyes the Purse Strings for Medicare"
Washington Post (07/16/09) Murray, Shailagh


Clinical Practice


About 45,000 Docs Qualify for Medicaid HIT Funding

The health information technology (HIT) funding in this years’ stimulus package includes additional funding for physicians who treat a large volume of Medicaid and poor patients. These physicians are eligible for up to $63,750 in Medicaid stimulus money over the next six years to install health information technology for electronic health records (EHRs). A study by the George Washington Medical Center found that about 45,000 physicians will qualify for the Medicaid stimulus funding if they demonstrate meaningful use of HIT for a patient mix that includes at least 30 percent Medicaid beneficiaries. Office-based pediatricians who do not meet the 30 percent Medicaid volume threshold but have at least 20 percent Medicaid patients will receive up to $42,500. Physicians who practice at federally qualified health centers or rural health centers can qualify if 30 percent of their patient base is characterized as "needy," including those covered by Medicaid, those who receive uncompensated care, and patients who are charged income-related sliding scale fees. The study estimated that nearly all (99 percent) health center physicians meeting a predominant practice standard will qualify for the Medicaid HIT incentives.

From "About 45,000 Docs Qualify for Medicaid HIT Funding"
HealthLeaders Media (07/08/09) Commins, John


Industry News


U.S. Is Poised to Enter Medical Isotope Market

An official from the U.S. National Nuclear Security Administration (NNSA) says the shutdown of Canada's National Research Universal Reactor, which supplies approximately 60 percent of the U.S. demand for medical isotopes, has created a "supply crisis," prompting the U.S. government to consider investing in medical isotope production. Parrish Staples, director of the U.S. Office of European and African Threat Reduction, says it would cost the U.S. government $120 million to set up a process for domestic production of molybdenum-99 using low-enriched uranium. The NNSA is now investigating possible technologies that would provide the United States with a secure, reliable source of isotopes without using any weapons-grade uranium. A House appropriations committee reportedly has approved $12 million to conduct the study.

From "U.S. Is Poised to Enter Medical Isotope Market"
Toronto Star (Canada) (07/10/09) Smith, Joanna
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