Fig 1: Confocal microscopy of magnetically labelled neural stem cells, showing co-staining of stem cells markers and iron particles.
Fig 2: Explicative picture showing the dimension of a mouse brain compared to a 1 euro cent coin.
Fig 3: Cartoon showing how intravenously injected neural stem cells migrate from the blood stream into the brain and differentiate in myelin-forming cells.
Fig 4: The mouse brain (A) has been analyzed on the coronal plane (as shown in B) both for histopathology (see myelin staining and conventional hematoxilin-eosin in C) and for in vivo MR images acquisition (see example in D). Thus, with MR it is possible to observe coronal slices of the brain of living mice.
Fig 5: MR images of the brain of an EAE mouse before immunization (A), in the acute phase of the disease, with a demyelinating lesion in the olfactory bulb (B, bright lesion in the circle), and after intravenous injection of magnetically labelled neural stem cells homing to the lesion (C, dark area in the circle).