-- RadioGraphics 1997; 17: 1497-1526

Figure Legend | Panel A | Panel B | Panel C | Panel D

Figure 2: Typical immunohistochemical profile of primary CNS B-cell lymphoma seen in serial sections (original magnification, x400) of the same tissue block. Panel A High-power photomicrograph (hematoxylin-eosin stain) shows a central blood vessel (V) surrounded by hemorrhage and a neoplastic cellular infiltrate. Panel B High-power photomicrograph (immunohistochemical stain for common leukocyte antigen) demonstrates brown cytoplasmic immunopositivity, an immunomarker for leukocytes. Panel C High-power photomicrograph (L26 stain with hematoxylin counterstain) shows large cells with pleomorphic nuclei that are immunopositive (stained brown), indicating their B-cell origin. Panel D High-power photomicrograph (CD3 stain with hematoxylin counterstain) shows an admixed population. The T cells, which are stained brown indicating they are immunopositive for CD3, are fewer in number than the nonstained neoplastic B cells. Compared with the pleomorphic nuclei of the B lymphocytes (arrowhead), the smaller, more regular nuclei of the T cells (arrow) indicate that they are a nonneoplastic, reactive component of the infiltrate.

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