-- RadioGraphics 1997; 17: 1497-1526

Figure Legend | Panel A | Panel B | Panel C | Panel D

Figure 16: Primary CNS lymphoma in a 35-year-old man with progressive vertigo and frontal headaches with unsteadiness and diplopia. Physical examination revealed vertical and horizontal nystagmus and ataxia. Panel A, Panel B Standard (A) and close-up (B) views of unenhanced sagittal T1-weighted MR images show a focal area of hypointensity (arrow in A) adjacent to the corpus callosum and enlargement of the right optic nerve (arrow in B). Panel C Contrast-enhanced sagittal T1-weighted MR image shows intense enhancement of the same region shown in A (arrow). Additional areas of enhancement are seen within the ventricular system, particularly the posterior body of the lateral ventricle (arrowhead). Panel D Contrast-enhanced sagittal T1-weighted MR image shows intense enhancement of the right optic nerve (arrow). There was additional involvement of the spinal cord and spinal leptomeninges (not shown). The working diagnosis was basilar meningitis of fungal or granulomatous cause. However, analysis of the stereotactic biopsy specimen demonstrated primary large cell lymphoma of T-cell origin.

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