From the Archives of the AFIP: Intralobar Sequestration

Radiologic-Pathologic Correlation

Abstract Introduction Postulated Pathogenesis Clinical Characteristics

Pathologic Features Histologic Features Radiologic Appearance

Therapy And Prognosis Conclusions Source Information References

Conclusions

Intralobar sequestration truly has "many faces" as Benjamin Felson, MD, wrote (22). The radiologic manifestations include recurrent focal air-space disease, a parenchymal mass, a cavitary consolidation or mass, and air or fluid-filled cystic lesions. Angiography is an excellent means of demonstrating the characteristic arterial supply to these lesions and is extremely helpful in surgical planning. Imaging studies such as CT and MR imaging may demonstrate cavitation, cystic changes, calcification, and the anomalous systemic vascular supply. Although extralobar sequestrations are clearly congenital in origin, previously published work in the pathologic literature dating back to 1959 supports an acquired origin for most cases of intralobar sequestration. We believe that although some intralobar sequestrations are congenital in origin, most cases represent a focal chronic inflammatory process that ultimately parasitizes normally occurring aortic branches within the pulmonary ligament to maintain its parenchymal viability.

Abstract Introduction Postulated Pathogenesis Clinical Characteristics

Pathologic Features Histologic Features Radiologic Appearance

Therapy And Prognosis Conclusions Source Information References