Glioblastoma Multiforme

Radiologic-Pathologic Correlation

Abstract Introduction Clinical Presentation Historical Perspective

Etiology and Genetics Pathologic Characteristics Radiologic-Pathologic Correlation

Therapy and Prognosis Conclusions Source Information References

Introduction

Primary tumors of the central nervous system are the fifth most common primary neoplasm, with an average incidence of five to 10 cases per 100,000 population per year (1). Approximately 50% of these tumors are astrocytomas, of which 50% are classified as glioblastoma multiforme (GBM) (2). Although it represents only 1%-2% of all malignancies, GBM is diagnosed in 15,000-20,000 patients per year, most of whom will die from their disease (3). Several recent studies have suggested that there is an increasing prevalence of primary brain neoplasms of all types, even allowing for such factors as earlier diagnosis because of advances in imaging technology (4), and this realization only serves to heighten interest in this devastating class of tumors. Quite often, the diagnosis of GBM is initially made or suggested on the basis of an imaging study, and it is therefore important for all radiologists to be aware of the many clinical and radiologic manifestations of this malignant tumor.

In this article, we demonstrate the wide spectrum of radiologic and pathologic findings in glioblastomas and discuss the latest information on the genetic basis of malignant gliomatous transformation and possible future therapeutic interventions. These observations are based on an extensive survey of the current literature and our own experience with more than 400 cases compiled over 40 years in the radiologic archives of the Armed Forces Institute of Pathology (AFIP).

Abstract Introduction Clinical Presentation Historical Perspective

Etiology and Genetics Pathologic Characteristics Radiologic-Pathologic Correlation

Therapy and Prognosis Conclusions Source Information References