Malignant Pleural Mesothelioma

Radiologic-Pathologic Correlation

Abstract Introduction Etiology and Epidemiology of MPM Clinical Features Microscopic Features Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

Gross Pathologic Characteristics Radiographic Features CT Features MR Imaging Findings Differential Diagnosis

Diagnostic Methods Staging and Resectability Treatment Prognosis Source Information References

References

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Return to: Introduction | Etiology and Epidemiology of MPM

2. Ribak J, Lilis R, Suzuki Y, Penner L, Selikoff IJ. Malignant mesothelioma in a cohort of asbestos insulation workers: clinical presentation, diagnosis, and causes of death. Br J Ind Med 1988; 45:182-187.
Return to: Introduction | Etiology and Epidemiology of MPM | Clinical Features

3. Craighead JE, Abraham JL, Churg A, et al. The pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema. Arch Pathol Lab Med 1982; 106:544-597.
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Return to: Etiology and Epidemiology of MPM

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Return to: Etiology and Epidemiology of MPM | Clinical Features

8. Hourihane DO, Lessof L, Richardson PC. Hyaline and calcified pleural plaques as an index of exposure to asbestos: a study of radiological and pathological features of 100 cases with a consideration of epidemiology. Br Med J 1966; 1:1069-1074.
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Return to: Etiology and Epidemiology of MPM | Differential Diagnosis

10. Hillerdal G. Pleural plaques and risk for bronchial carcinoma and mesothelioma: a prospective study. Chest 1994; 105:144-150.
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14. Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in northwestern Cape Province. Br J Ind Med 1960; 17:260-271.
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19. Selikoff IJ, Hammond EC, Seidman H. Latency of asbestos disease among insulation workers in the United States and Canada. Cancer 1980; 46:2736-2740.
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20. Rusch VW, Piantadosi S, Holmes EC. The role of extrapleural pneumonectomy in malignant pleural mesothelioma. J Thorac Cardiovasc Surg 1991; 102:1-9.
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21. Pisani RJ, Colby TV, Williams DE. Malignant mesothelioma of the pleura. Mayo Clin Proc 1988; 63:1234-1244.
Return to: Etiology and Epidemiology of MPM | Diagnostic Methods | Staging and Resectability | Treatment

22. Fraire AE, Cooper S, Greenberg SD, Buffler P, Langston C. Mesothelioma of childhood. Cancer 1988; 62:838-847.
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23. Hammar SP, Bockus D, Remington F, Friedman S, LaZerte G. Familial mesothelioma: a report of two families. Hum Pathol 1989; 20:107-112.
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24. McDonald JC, McDonald AC. Epidemiology of mesothelioma: from estimated incidence. Prev Med 1977; 6:426-446.
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25. Roggli VL, McGavran MH, Subach J, Sybers HD, Greenberg SD. Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma: a study of 25 cases. Cancer 1982; 50:2423-2432.
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26. Peterson JT Jr, Greenberg SD, Buffler PA. Non-asbestos-related malignant mesothelioma: a review. Cancer 1984; 54:951-960.
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27. Baris YI, Artvinli M, Sahin AA. Environmental mesothelioma in Turkey. Ann NY Acad Sci 1979; 79:423-432.
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28. Sahin AA, Coplu L, Selcuk ZT, et al. Malignant pleural mesothelioma caused by environmental exposure to asbestos or erionite in rural Turkey: CT findings in 84 patients. AJR 1993; 161: 533-537.
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29. Erzen C, Eryilmaz M, Kalyoncu F, Bilir N, Sahin A, Baris YI. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite). J Comput Assist Tomogr 1991; 15:256- 260.
Return to: Etiology and Epidemiology of MPM

30. Hillerdal G, Berg J. Malignant mesothelioma secondary to chronic inflammation and old scars: two new cases and review of the literature. Cancer 1985; 55:1968-1972.
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31. Adams VI, Unni KK, Muhm JR, Jett JR, Ilstrup DM, Bernatz PE. Diffuse malignant mesothelioma of pleura: diagnosis and survival in 92 cases. Cancer 1986; 58:1540-1551.
Return to: Clinical Features | Differential Diagnosis | Diagnostic Methods

32. Antman KH. Malignant mesothelioma. N Engl J Med 1980; 303:200-202.
Return to: Clinical Features | Diagnostic Methods | Prognosis

33. Aisner J. Current approach to malignant mesothelioma of the pleura. Chest 1995; 107: 332S-344S.
Return to: Clinical Features | Diagnostic Methods | Treatment | Prognosis

34. Ruffie P. Pleural mesothelioma. Curr Opin Oncol 1992; 4:334-341.
Return to: Clinical Features

35. Roggli VL, Sanfilippo F, Shelburne JD. Mesothelioma. In: Roggli VL, Greenberg SD, Pratt PC, eds. Pathology of asbestos-associated diseases. New York, NY: Little, Brown, 1992; 109-153.
Return to: Microscopic Features | Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy | Gross Pathologic Characteristics

36. Wick MR, Loy T, Mills SE, Legier JF, Manivel JC. Malignant epithelioid pleural mesothelioma versus peripheral pulmonary adenocarcinoma: a histochemical, ultrastructural, and immunohistologic study of 103 cases. Hum Pathol 1990; 21:759-766.
Return to: Microscopic Features

37. Cibas ES, Corson JM, Pinkus GS. The distinction of adenocarcinoma from malignant mesothelioma in cell blocks of effusions: the role of routine mucin histochemical assessment of carcinoembryonic antigen, keratin proteins, epithelial membrane antigen, and milk fat globule- derived antigen. Hum Pathol 1987; 18: 67-74.
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38. Otis CN, Carter D, Cole S, Battifora H. Immunohistochemical evaluation of pleural mesothelioma and pulmonary adenocarcinoma. Am J Surg Pathol 1987; 11:445-456.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

39. Sheibani K, Battifora H, Burke J. Antigenic phenotype of malignant mesotheliomas and pulmonary adenocarcinomas: an immunohistochemical analysis demonstrating the value of Leu-M1 antigen. Am J Pathol 1986; 123:212- 219.
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40. Szpak CA, Johnson WW, Roggli V. The diagnostic distinction between malignant mesothelioma of the pleura and adenocarcinoma of the lung as defined by a monoclonal antibody (B72.3). Am J Pathol 1986; 122:252-260.
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41. Goffey MJ, Mills SE, Swanson PE, Zarbo RJ, Shah AR, Wick MR. Immunoreactivity for BER-EP4 in adenocarcinomas, adenomatoid tumors, and malignant mesotheliomas. Am J Surg Pathol 1992; 16:593-599.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

42. Colins CL, Ordones NG, Schaefer R, et al. Thrombomodulin expression in malignant pleural mesothelioma and pleural adenocarcinoma. Am J Pathol 1992; 141:827-833.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

43. O'Hara CJ, Corson JM, Pinkus GS, Stahel RA. ME1: a monoclonal antibody that distinguishes epithelial-type malignant mesothelioma from pulmonary adenocarcinoma and extrapulmonary malignancies. Am J Pathol 1990; 136:421- 428.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

44. Amin KM, Litzky LA, Smythe WR, et al. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol 1995; 146: 344-356.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

45. Dewar A, Valente M, Ring NP, Corrin B. Pleural mesothelioma of epithelial type and pulmonary adenocarcinoma: an ultrastructural and cytochemical comparison. J Pathol 1987; 152: 309-316.
Return to: Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

46. Huncharek M. Miliary mesothelioma. Chest 1994; 106:605-606.
Return to: Gross Pathologic Characteristics | Radiographic Features

47. Huncharek M, Muscat J. Metastases in diffuse pleural mesothelioma: influence of histological type. Thorax 1987; 42:897-898.
Return to: Gross Pathologic Characteristics

48. Harrison RN. Sarcomatous pleural mesothelioma and cerebral metastases: case report and a review of eight cases. Eur J Respir Dis 1984; 65:185-188.
Return to: Gross Pathologic Characteristics

49. Solomons K, Polakow R, Marchand P. Diffuse malignant mesothelioma presenting as bilateral malignant lymphangitis. Thorax 1985; 40:682- 683.
Return to: Gross Pathologic Characteristics | Radiographic Features

50. Wechsler RJ, Rao VM, Steiner RM. The radiology of thoracic malignant mesothelioma. Crit Rev Diagn Imaging 1983; 20:283-310.
Return to: Radiographic Features | CT Features | Differential Diagnosis

51. Huncharek M, Smith K. Extrathoracic lymph node metastases in malignant pleural mesothelioma (letter). Chest 1988; 93:443-444.
Return to: Radiographic Features

52. Campbell GD, Greenberg SD. Pleural mesothelioma with calcified liver metastases. Chest 1981; 79:229-230.
Return to: Radiographic Features

53. Kawashima A, Libshitz HI. Malignant pleural mesothelioma: CT manifestations in 50 cases. AJR 1990; 155:965-969.
Return to: CT Features

54. Leung AN, MÄller NL, Miller RR. CT in differential diagnosis of diffuse pleural disease. AJR 1990; 154:487-492.
Return to: CT Features | Differential Diagnosis

55. Rusch V, Saltz L, Venkatraman E, et al. A phase II trial of pleurectomy/decortication followed by intrapleural and systemic chemotherapy for malignant pleural mesothelioma. J Clin Oncol 1994; 12:1156-1163.
Return to: CT Features | Treatment

56. Patz EF Jr, Shaffer K, Piwnica-Worms DR, et al. Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability. AJR 1992; 159:961-966.
Return to: CT Features | MR Imaging Findings | Staging and Resectability

57. Rusch VW, Godwin JD, Shuman WP. The role of computed tomography scanning in the initial assessment and the follow-up of malignant pleural mesothelioma. J Thorac Cardiovasc Surg 1988; 96:171-177.
Return to: CT Features

58. Sahn SA. Malignant pleural effusions. In: Fishman AP, ed. Pulmonary diseases and disorders. 2nd ed. New York, NY: McGraw-Hill, 1988; 2159-2170.
Return to: Differential Diagnosis

59. Di Bonito L, Falconieri G, Colautti I, Bonifacio Gori D, Dudine S, Giarelli L. Cytopathology of malignant mesothelioma: a study of its patterns and histological bases. Diagn Cytopathol 1993; 9:25-31.
Return to: Diagnostic Methods

60. Boutin C, Rey F. Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. I. Diagnosis. Cancer 1993; 72:389-393.
Return to: Diagnostic Methods | Staging and Resectability

61. Metintas M, Ozdemir N, Isiksoy S, et al. CT-guided pleural needle biopsy in the diagnosis of malignant mesothelioma. J Comput Assist Tomogr 1995; 19:370-374.
Return to: Diagnostic Methods

62. Boutin C, Astoul P, Rey F, Viallat JR. Malignant mesothelioma. In: Brown WT, ed. Atlas of video-assisted thoracoscopic surgery. New York, NY: Saunders, 1994; 171-183.
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Return to: Staging and Resectability

64. Boutin C, Rey F, Gouvernet J, Viallat JR, Astoul P, Ledoray V. Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. II. Prognosis and staging. Cancer 1993; 72:394-404.
Return to: Staging and Resectability

65. International Mesothelioma Interest Group. A proposed new international TNM staging system for malignant pleural mesothelioma. Chest 1995; 108:1122-1128.
Return to: Staging and Resectability

66. Allen KB, Faber LP, Warren WH. Malignant pleural mesothelioma: extrapleural pneumonectomy and pleurectomy. Chest Surg Clin North Am 1994; 4:113-126.
Return to: Treatment

67. Sugarbaker DJ, Heher EC, Lee TH, et al. Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma. J Thorac Cardiovasc Surg 1991; 102:10-15.
Return to: Treatment

68. Pass HI. Contemporary approaches in the investigation and treatment of malignant pleural mesothelioma. Chest Surg Clin North Am 1994; 4:497-515.
Return to: Treatment

69. Astoul P, Viallat JR, Laurent JC, Brandely M, Boutin C. Intrapleural recombinant IL-2 in passive immunotherapy for malignant pleural effusion. Chest 1993; 103:209-213.
Return to: Treatment

70. Boutin C, Nussbaum E, Monnet I, et al. Intrapleural treatment with recombinant gamma-interferon in early stage malignant pleural mesothelioma. Cancer 1994; 74:2460-2467.
Return to: Treatment

71. Keller SM. Adjuvant therapy for malignant pleural mesothelioma. Chest Surg Clin North Am 1994; 4:127-135.
Return to: Treatment

72. Van Gelder T, Damhuis RA, Hoogsteden HC. Prognostic factors and survival in malignant pleural mesothelioma. Eur Respir J 1994; 7:1035-1038.
Return to: Prognosis

Abstract Introduction Etiology and Epidemiology of MPM Clinical Features Microscopic Features Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

Gross Pathologic Characteristics Radiographic Features CT Features MR Imaging Findings Differential Diagnosis

Diagnostic Methods Staging and Resectability Treatment Prognosis Source Information References