Malignant Pleural Mesothelioma

Radiologic-Pathologic Correlation

Abstract Introduction Etiology and Epidemiology of MPM Clinical Features Microscopic Features Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

Gross Pathologic Characteristics Radiographic Features CT Features MR Imaging Findings Differential Diagnosis

Diagnostic Methods Staging and Resectability Treatment Prognosis Source Information References

MR Imaging Findings

MPM typically has minimally increased signal intensity relative to that of the adjacent chest wall musculature on T1-weighted images (Figure 28). On T2-weighted images, MPM has moderately increased signal intensity relative to muscle. MPM extension results in increased signal intensity on the T2-weighted images (Figure 29). MR imaging has some advantage over CT, as imaging in all three planes probably improves the detection of chest wall, diaphragmatic, and mediastinal invasion and helps to better predict overall resectability (Figure 30, Figure 31) (56). However, false-positive and false-negative results in the prediction of resectability have also been reported, and a combination of imaging and diagnostic modalities may be required to evaluate the true extent of disease (56). Diffuse, subtle, superficial spread of MPM throughout the pleural space is difficult to detect by any means (56).

Abstract Introduction Etiology and Epidemiology of MPM Clinical Features Microscopic Features Characterization of MPM with Histochemistry, Immunochemistry, and Electron Microscopy

Gross Pathologic Characteristics Radiographic Features CT Features MR Imaging Findings Differential Diagnosis

Diagnostic Methods Staging and Resectability Treatment Prognosis Source Information References