Gestational Trophoblastic Disease

Radiologic-Pathologic Correlation

Abstract Introduction Normal And Abnormal Trophoblast Epidemiologic Characteristics

Hydatidiform Mole Complete Hydatidiform Mole Invasive Mole Choriocarcinoma Partial Hydatidiform Mole

Placental Site Trophoblastic Disease Conclusions Source Information References

Hydatidiform Mole

Hydatidiform mole constitutes 80% of cases of GTD and includes both complete hydatidiform mole (also called classic hydatidiform mole) and partial hydatidiform mole (2). These are noninvasive processes that demonstrate both proliferation and hydropic swelling of the villi. At histologic analysis, the villi have a prominent, central acellular space (7), which accounts for the macroscopic appearance of fluid-filled vesicles (Figure 1, Figure 2). Occasionally, necrosis is seen (11). In addition, microscopic evaluation shows trophoblastic hyperplasia (Figure 3), which accounts for the characteristic marked elevation of beta-hCG levels, which may lead to hyperemesis or development of theca lutein cysts.

Complete hydatidiform mole, invasive mole, and choriocarcinoma are discussed in sequence because the latter two entities are often sequela of complete hydatidiform mole. Partial hydatidiform mole is discussed separately.

Abstract Introduction Normal And Abnormal Trophoblast Epidemiologic Characteristics

Hydatidiform Mole Complete Hydatidiform Mole Invasive Mole Choriocarcinoma Partial Hydatidiform Mole

Placental Site Trophoblastic Disease Conclusions Source Information References