Incidental Adrenal Lesions: Principles, Techniques, and Algorithms for Imaging Characterization
 A 17-cm left adrenal cyst in 43-year-old woman. (a) Sagittal ultrasound image shows a complex cyst with marked internal echoes (arrow). (b) Axial contrast-enhanced CT scan shows slightly thickened wall (short arrow) and cyst with mixed components (long arrow). Owing to the cyst's complex nature, percutaneous biopsy was performed to exclude cystic neoplasm; results confirmed benign adrenal cyst. (Radiology 2008;249:756–775) © RSNA, 2008. All rights reserved. Printed with permission. |
While almost all incidental adrenal lesions (IALs) in patients without a known primary cancer are benign, characterization of IALs in patients with cancer is essential to predict prognosis of the primary disease, assess staging and direct therapy.
In a review article in the December issue of Radiology (RSNA.org/radiology), Giles W.L. Boland, M.D., and colleagues evaluate the anatomic and physiologic imaging principles used for differentiating adrenal masses, present available imaging techniques and recommend an imaging algorithm that can guide the radiologist toward the correct diagnosis.
High test specificity is the crux of adrenal imaging, according to the researchers. Techniques addressed include:
• Morphologic imaging: CT and MR imaging
• Lipid-sensitive imaging techniques: CT and MR imaging
• CT techniques including CT densitometry and CT histogram analysis
• MR imaging techniques including chemical shift
• Perfusion imaging of the adrenal glands: CT washout scans
Also analyzed are imaging features of cortical adenoma, metastasis, myelolipoma, lymphoma, adrenal carcinoma, pheochromocytoma, hemorrhage, cyst, neuroblastoma, ganglioneuroma, hemangioma and hemangiosarcoma and granulomatous disease.
While the importance of adrenal imaging methods continues to evolve, the researchers found that "CT contrast medium washout tests offer the highest test sensitivity and specificity for IAL characterization."