Below are just a few of the many success stories of R&E Foundation grant recipients.
Yvonne Lui, MDAssociate Professor of Radiology, Neuroradiology Section ChiefNYU Langone Medical Center
“HCC is a major global burden of morbidity and mortality and its incidence in the U.S. has tripled over the past 30 years,” Dr. Woodrum said. “Locoregional thermal ablative therapies are important treatment options for early-mid stage HCC, achieving short-term outcomes similar to surgery with less morbidity. However, high tumor recurrence rates after treatment of larger HCCs (up to 75 percent at 5 years) limit their applicability and overall survival remains poor for these patients,” Dr. Woodrum said. “We will use a combination of cellular and molecular methods, novel imaging techniques and in vitro, in vivo and patient-based approaches to systematically investigate the mechanistic role of the novel heat stress induced MET/EGFR-PI3K-AKT axis in HCC thermal resistance, recurrence and tumor progression.”